Test Directory

Test Code
U23DI
Test Name
2,3-Dinor 11 Beta-Prostaglandin F2 Alpha
CPT Codes
84150
Included Tests
  • 2,3-dinor 11B-Prostaglandin F2a
  • Creatinine, 24 HR
  • Creatinine Concentration, 24 HR
Expected Turnaround Time
3 - 8 days
Clinical Utility
Screening for mast cell activation disorders including systemic mastocytosis using 24-hour urine specimens
Specimen and Container Info

Specimen Type: 24 Hour Urine

  

Collection Container: 24 Hour Plastic Urine Container

    

Desired Specimen Volume: 5 mL

Collection Instructions
  1. Collect 24-hour urine in a timed urine collection jug.
  2. Maintain refrigerated.
Processing and Submission Instructions
  1. Transfer 5 mL of urine into clear aliquot tubes (screw caps).
  2. Specimen volume (in milliliters) and duration (in hours) are required.
  3. Total volume must be at least 300 mL.
Patient Preparation

Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If medically feasible, for 2 weeks before specimen collection, patient should not take aspirin and for 72 hours before specimen collection, patient should not take NSAIDs.

Transport Instructions

Transport to the laboratory refrigerated. 

Stability Requirements

Room Temperature

72 hours

Refrigerated

28 days

Frozen

28 days

Methodology
Varies By Test
Reference Intervals

See patient report.

Limitations

Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.

Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine.

Patients taking aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha if dosage has not been discontinued for 2 weeks or 72 hours, respectively.

Alternate Names
  • 11 Beta-Prostaglandin F2 Alpha
  • 11BPG
  • 2,3 11 Beta-Prostaglandin F2 Alpha
  • 23BPG
  • BPG2
  • Mastocytosis
  • Prostaglandin
  • 23BPT
  • 23
  • BPT23
Reference Lab
Mayo Clinic Laboratories
Testing Schedule
Routine, 2 times per week