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Test Code
ADALX
Test Name
Adalimumab Quantitative with Reflex to Antibody
CPT Codes
80145
Expected Turnaround Time
2 - 4 days
Clinical Utility
Therapeutic drug monitoring of adalimumab concentration and antibody levels, if appropriate
Specimen and Container Info

Specimen Type: Serum

Preferred Collection Container: Gold Top, Serum Separator

Alternate Collection Container: Red Top, Plain

Desired Specimen Volume: 0.5 mL
Collection Instructions
  1. Collect a gold top, serum separator tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 0.5 mL of serum to a clear aliquot tube (screw cap).
Patient Preparation
For 12 hours before specimen collection, it is recommended that the patient not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Refrigerated

28 days

Frozen

28 days
Causes for Rejection
  • Heat-treated specimens
Methodology
Enzyme Linked Immunosorbent Asasy (Elisa)
Reference Intervals

See patient report.
Limitations

Tumor necrosis factor (TNF) measurement is not the analyte of choice for monitoring therapy with TNF inhibitors (such as adalimumab or infliximab) since TNF testing would not distinguish between free TNF and TNF bound to the monoclonal antibody, either in the extracellular or membrane-bound form of the cytokine.

Toxicity effects other than acute hypersensitivity infusion reactions have not been described nor correlated with high adalimumab concentrations.

Optimal therapeutic concentrations of adalimumab may vary according to the disease. For adults with active inflammatory bowel disease, a concentration of 7.5 mcg/mL or greater is considered therapeutic.
Alternate Names
  • Humira
  • Amjevita
  • Adalimumab
Reference Lab
Mayo Clinic Laboratories
Testing Schedule
Routine, 3 times per week
Reflex Tests
ADAAB
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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