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Test Code
ALPRZ
Test Name
Alprazolam, Quantitative, Whole Blood
CPT Codes
AMA 80346, CMS G0480
Expected Turnaround Time
5 - 7 days
Clinical Utility

Useful in determining the use or abuse of Alprazolam.

Testing includes identification and quantitation of:

  • Alprazolam
  • Alphahydroxyalprazolam (Alprazolam Metabolite)
Specimen and Container Info

Specimen

Container

Volume

Whole Blood

Grey Top* (Sodium Fluoride, Potassium Oxalate)

3 mL

Whole Blood

Dark Green Top (Lithium Heparin)

3 mL

Whole Blood

Lavender Top (EDTA)

3 mL

Serum

Red Top, Plain

1 mL

*Preferred Specimen
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Room Temperature

7 days

Refrigerated

7 days
Causes for Rejection

Specimens collected in separator tubes will be rejected. 
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Intervals

Analyte

Therapeutic Range (ng/mL)

Alprazolam

10 - 100

Alpha - hydroxyalprazolam

Not established*

*Alpha - hydroxyalprazolam has 65% pharmacological activity of Alprazolam.
Limitations

Analyte

Reporting Limit (ng/mL)

Alprazolam

5

Alphahydroxyalprazolam

5
Performing Location
Roble Road Core Laboratory
Alternate Names
  • Alphahydroxyalprazolam
  • Xanax
  • Alprax
  • Alzam
  • Tranax
Testing Schedule
Routine, 2 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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