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Test Code
AMPHI
Test Name
Amphiphysin Antibody, IgG
CPT Codes
83516
Expected Turnaround Time
4 - 7 days
Clinical Utility
Consider ordering in individuals with stiff-person syndrome, paraneoplastic encephalomyelitis (PEM), and sensory neuropathy (SN). May aid in diagnosis of occult tumor, recurrence of tumor, or second tumor.
Specimen and Container Info

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 1 mL
Collection Instructions
  1. Collect a gold top, serum separator tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells within 2 hours of collection.
  2. Transfer 1 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

48 hours

Refrigerated

14 days

Frozen

1 month
Causes for Rejection
  • Plasma
  • Contaminated heat-inactivated, hemolyzed, or lipemic samples
Methodology
Qualitative Immunoblot
Reference Intervals

See patient report.
Limitations

Amphiphysin antibody is present in about 5 percent of patients with stiff-person syndrome and is found variably in other causes of paraneoplastic neurological syndrome (PNS). Amphiphysin antibody is mainly associated with small-cell lung cancer and breast tumors.
Alternate Names
  • Stiff-man
  • PERM
  • Sensory neuropathy
  • Progressive encephalomyelitis
  • Stiff-person
Reference Lab
Labcorp Of America Holdings
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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