Test Directory

The detection of anti-RNAP III antibodies is useful in the diagnosis of SSc and for the identification of patients at risk for developing progressive skin thickening and renal crisis. The prevalence of IgG RNAP III antibodies is from 3 - 58% in SSc patients.

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Alternate Collection Container: Red Top, Plain

Desired Specimen Volume: 1 mL

1. Collect specimen in gold top, serum separator tube via venipuncture.

1. Separate serum from cells within one hour of collection
2. Transfer 1 mL of serum to a clear aliquot tube.

Transport to the laboratory refrigerated. 

• Grossly hemolyzed
• Bacterial contamination
• Lipemic
• Icteric
• Non-serum specimen types

See patient report.

• Anti-RNA Polymerase 3 Ab
• Anti-RNAP III
• RNA Polymerase III