Test Directory

Test Code
B2GP
Test Name
Beta-2-Glycoprotein 1 Autoantibody Profile
CPT Codes
86146 X 3
Included Tests
  • Beta-2-Glycoprotein 1 IgA (AB2GP)
  • Beta-2-Glycoprotein 1 IgG (GP2GP)
  • Beta-2-Glycoprotein 1 IgM (MB2GP)
Expected Turnaround Time
4 - 7 days
Clinical Utility

Beta-2-Glycoprotein 1 autoantibodies are found in patients with antiphospholipid syndrome (APS) and are associated with increased risk of venous and arterial thrombosis and thrombocytopenia. Beta-2-Glycoprotein 1 autoantibodies are found only in patients with autoimmune diseases, while cardiolipin autoantibodies can be transiently found in infectious diseases.

Specimen and Container Info

Preferred Specimen Type: Serum

Desired Specimen Volume: 2 mL

Preferred Collection Container: Gold Top, Serum Separator

Processing and Submission Instructions

Separator tubes: Contains clot activator and gel for separating serum from cells, but not anticoagulant. Separate serum from cells as soon as the clot has formed (30 minutes). If specimen is centrifuged before clotting is complete, a fibrin clot will form on top of the cell. This may cause the gel barrier to not be intact and could cause improper separation of serum and cells, possibly affecting test results.

Transport Instructions

Transport refrigerated.

Stability Requirements

Refrigerated

7 days

Frozen

<20°C for long-term storage.

Freeze/Thaw Cycles

Avoid multiple freeze/thaw cycles.

Methodology
Semi-Quantitative Multiplex Bead Assay
Reference Intervals

Beta-2-Glycoprotein 1 IgG, IgA or IgM: <20 U/mL, no antibodies detected

Performing Location
Roble Road Core Laboratory
Testing Schedule
Routine, Monday - Friday no holidays