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Test Code
CHPOC
Test Name
Chromosome, Product of Conception Battery
CPT Codes
CPTs 88233, 88262 (note: If the Chromosome Analysis result is 'Failure, normal or no growth', Chromosome Microarray-SNP will be performed at an additional charge with CPT code 81229.
Included Tests

If the Chromosome Analysis result is 'Failure, normal or no growth', Chromosome Microarray-SNP will be performed at an additional charge (CPT code 81229).
Clinical Utility

Description:

Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions.
Specimen and Container Info

Specimen: Nonfixed - Chorionic Villus Sampling (CVS) or Product of Conception (POC)

Collection Container: Sterile container with transport medium (Kit is provided by the HNL Lab Medicine Cytogenetics Department)

Desired Specimen Size: 5x5mm tissue

Minimum Acceptable Specimen Size: 2x3mm tissue
Collection Instructions

Specimen should be aseptically collected and placed in a sterile collection container with transport medium.
Processing and Submission Instructions

Each specimen must be accompanied by an electronic order, or requisition form, or script, or physician note.
Transport Instructions
  • Transport to the laboratory at room temperature.
  • Store specimen in a sterile collection container with transport medium at room temperature and deliver to lab within 24 hours.
  • If specimen cannot be delivered within 24 hours, store in refrigerator. Do not freeze specimen.
  • Specimens collected on the weekends must be refrigerated upon arrival at HNL Lab Medicine.
Stability Requirements

Room Temperature

24 hours

Refrigerated

48 - 72 hours

Frozen

Do not freeze

Freeze/Thaw Cycles

Do not freeze
Causes for Rejection
  • Specimens arriving without any form of patient identification.
  • Specimen is in a fixative.
  • Specimen frozen.
  • Necrotic tissue submitted.
  • Specimen is contaminated.
Methodology
G-BANDING, Cytogenetic Analysis
Reference Intervals

Reference Range: 20 cell analysis on a G banded preparation is performed for complete evaluation. If the cultures for chromosome analysis fail or the result of the test is normal, the test will be reflexed to microarray.
Limitations

Traditional G-banded chromosome analysis for POC yields low resolution structural and numerical analysis of the chromosomes, while CMA provides high-definition copy number analysis. This test cannot confidently differentiate between fetal and maternal tissue.
Performing Location
Roble Road Core Laboratory
Alternate Names
  • Karyotype, Product of Conception
  • Chromosome Analysis, POC
  • POC
  • Prenatal
Testing Schedule
Routine, Monday - Friday no holidays
Disease Group
Cytogenetic Tests
Reflex Tests
ARPOC
What triggers the reflex testing
If the Product of Conception (POC) chromosome analysis is normal, the testing failed, or the culture had no growth, there will be a reflex to microarray testing.
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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