Test Directory

• Myelin Oligodendrocyte Glycoprotein FACS
• Neuromyelitis Optica/Aquaporin-4-IgG FACS

Useful for:

• Diagnosis of inflammatory demyelinating diseases (IDDs) with similar phenotype to neuromyelitis optica spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis
• Diagnosis of autoimmune myelin oligodendrocyte glycoprotein-opathy
• Diagnosis of neuromyelitis optica
• Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
• Diagnosis of ADEM
• Prediction of a relapsing disease course

Specimen Type: Serum

Preferred Collection Container: Red Top, Plain

Alternate Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 3 mL

1. Collect a red top, plain tube via venipuncture.

1. Separate serum from cells.
2. Transfer 3 mL of serum to a clear aliquot tube (screw cap).

For optimal antibody detection, specimen collection is recommended before initiation of immunosuppressant medication.

Transport to the laboratory refrigerated. 

• Gross hemolysis
• Gross lipemia
• Gross icterus

See patient report.

Aquaporin-4-IgG and myelin oligodendrocyte glycoprotein-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

• ADEM
• AQP4
• Aquaporin
• Devic's Antibody
• NMO (Neruomyelitis Optica)
• NMO-IgG
• Optic Neuritis Antibody
• Transverse Myelitis Antibody
• Vision Loss Antibody