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Test Code
DB1AB
Test Name
Diabetes Type 1 Autoantibody Panel
CPT Codes
86337, 86341 X 3
Included Tests
  • Glutamic Acid Decarboxylase 65 Ab
  • Insulin Autoantibody
  • IA-2 Antibody
  • Zinc Transporter 8 (ZnT8) Antibody
Expected Turnaround Time
6 - 7 days
Clinical Utility

The American Diabetes Association supports using autoantibody (AAb) screening to diagnose T1D. T1D autoantibodies are markers of ongoing damage to insulin-producing beta cells. The four AAbs used in clinical practice to diagnose T1D are: AAbs against insulin (IAA), tyrosine phosphatase IA2 (IA2A), glutamic acid decarboxylase (GAD65), and zinc transporter. Numerous clinical trials demonstrate important clinical benefits associated with detecting T1D using an AAb screening approach.

Clinical guidelines have been established to help identify T1D at its earliest phases and before progression to DKA, providing presymptomatic and symptomatic staging of T1D.
Specimen and Container Info

Specimen Type: Serum 

 

Collection Container: Gold Top, Serum Separator 

Alternate Collection Container: Red Top, Plain 

 

Desired Specimen Volume: 4 mL
Collection Instructions
  1. Collect a gold top, serum separator tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 4 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory frozen
Stability Requirements

Room Temperature

7 days

Refrigerated

7 days

Frozen

28 days
Causes for Rejection
  • Gross hemolysis
  • Lipemia
  • Icterus
  • Specimens other than serum
Methodology
Varies By Test
Reference Intervals

See patient report.
Alternate Names
  • Insulin autoantibody (IAA),
  • Tyrosine phosphatase (IA2)
  • Zinc transporter 8 (ZnT8)
  • Glutamic acid decarboxylase (GAD65)
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Routine, 2 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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