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Test Code
EACSF
Test Name
Encephalitis Ab Eval w/refl Titer and LB, CSF
CPT Codes
83519, 86052, 86255 X 19, 86341
Included Tests
  • Ma2/Ta Ab, IFA
  • Myelin Ab, IFA
  • DPPX Ab, CBA, IFA
  • Tissue IFA Observation
  • ANNA1 (Hu) Ab, IFA
  • ANNA2 (Ri) Ab, IFA
  • ANNA3 Ab, IFA
  • PCA1 (Yo) Ab, IFA
  • PCA2 Ab, IFA
  • PCA TR (DNER) Ab, IFA
  • AGNA (SOX1) Ab, IFA
  • Amphiphysin Ab, IFA
  • CRMP5 (CV2) Ab, IFA
  • GAD65 Ab, IFA
  • Aquaporin 4 Ab, IFA
  • Aquaporin 4 (AQP4) Ab,CBA, IFA
  • NMDAR1 Ab, CBA, IFA
  • AMPAR1 Ab, CBA, IFA
  • AMPAR2 Ab, CBA, IFA
  • GABABR Ab, CBA, IFA
  • LGI1 Ab, CBA, IFA
  • CASPR2 Ab, CBA, IFA
  • VGKC Ab, RIA
Expected Turnaround Time
5 - 14 days
Clinical Utility

Encephalitis due to anti-neuronal autoantibodies may present in a variety of ways and may be associated with a variety of tumors. Screening for anti-neuronal autoantibodies is performed using tissue immunofluorescence with confirmation by line blot assay. This CSF panel also includes additional testing for autoantibodies frequently associated with encephalitis such as NMDA receptor using cell-based assays. Testing using both serum and CSF increases sensitivity for detection.
Specimen and Container Info

Specimen Type: CSF

Collection Container: Sterile Container (Preservative Free)

Desired Specimen Volume: 4 mL
Collection Instructions
  1. Collect CSF via lumbar puncture.
Processing and Submission Instructions
  1. Transfer 4 mL of CSF to a sterile aliquot tube (red screw cap).
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Room Temperature

24 hours

Refrigerated

7 days

Frozen

21 days
Causes for Rejection
  • Received room temperature
Methodology
Varies By Test
Reference Intervals

See patient report.
Alternate Names
  • Encephalitis Antibody Evaluation with Reflex to Titer and Line Blot, CSF
  • Autoimmune panel
  • Autoimmune Encephalitis Panel
  • Neuroimmunology
  • Encephalitis panel
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Varies
Reflex Tests
A3CSF, ABTRT, AQCSF, CACSF, DAR1T, DNCSF, DPCSF, GACSF, LGCSF, MYCSF, NYCSF, PAR1T, PAR2T, PCCSF
What triggers the reflex testing
If screen suggests a fluorescence pattern consistent with one or more antibodies then a line blot consisting of 10 antibodies will be performed. If screen suggests a fluorescence pattern consistent with ANNA3, PCA2,or Myelin Ab then titer will be performed. If AQP4, NMDAR1, AMPAR1/2, LGI1, CASPR2, DPPX or GABABR are positive, then titer will be performed.
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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