Test Directory

Clear All
Test Code
EASER
Test Name
Encephalitis Antibody Evaluation with Reflex to Titer and Line Blot, Serum
CPT Codes
83519 X 2, 86052, 86255 X 19, 86341, 86596 X 2
Included Tests
  • Tissue IFA Observation(s)
  • ANNA1 (Hu) Ab, IFA
  • ANNA2 (Ri) Ab, IFA
  • ANNA3 Ab, IFA
  • PCA1 (Yo) Ab, IFA
  • PCA2 Ab, IFA
  • PCA-Tr (DNER) Ab, IFA
  • AGNA/SOX1 Ab, IFA
  • Amphiphysin Ab, IFA
  • CRMP5/CV2 Ab, IFA
  • GAD65 Ab, IFA
  • Ma2/Ta Ab, IFA
  • Myelin Ab, IFA
  • Aquaporin 4 (NMO) Ab, IFA
  • Aquaporin-4 Ab (IgG),CBA
  • NMDAR1 Ab, CBA
  • AMPAR1 Ab, CBA
  • AMPAR2 Ab, CBA
  • GABABR Ab, CBA
  • LGI1 Ab, CBA
  • CASPR2 Ab, CBA
  • DPPX Receptor Ab, CBA IFA
  • AChR Ganglionic(Alpha3)Ab
  • VGCC Type P/Q Ab
  • VGCC Type N Ab
  • VGKC Ab
Expected Turnaround Time
5 - 14 days
Clinical Utility

The Encephalitis Antibody Panel provides an evaluation of possible autoantibodies in patients with suspected autoimmune encephalitis, and optimizes the likelihood of detecting neuronal specific autoantibodies, whether present singly or occurring as multiple autoantibodies.
Specimen and Container Info

Specimen Type: Serum

Preferred Collection Container: Red Top, Plain

Alternate Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 8 mL
Collection Instructions
  1. Collect 2 red top plain tubes via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 8 mL of serum to clear aliquot tubes (screw caps).
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Room Temperature

24 hours

Refrigerated

14 days

Frozen

21 days

Freeze/Thaw Cycles

Stable x2
Causes for Rejection
  • Gross hemolysis
  • Grossly lipemic
  • Grossly icteric
  • Turbid 
  • Bacterial contamination
Methodology
Varies By Test
Reference Intervals

See patient report.
Alternate Names
  • Encephalitis Ab Eval w/refl Titer and LB, S
  • Encephalopathy-Autoimmune Evaluation
  • Autoimmune Encephalitis Panel
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Varies
Reflex Tests
1NMDA, 2AMPA, 2CASP, ABGAB, ABMYE, ABNEU, AMPAR, ANA3T, AQP4T, DPPXA, LGI1A, MAGGM, MAGSG, MAIGM, PCCAB, PDNER, PURK2
What triggers the reflex testing
A line blot consisting of 10 analytes will be performed at an additional charge as a reflex for tissue mosaic IFA suggesting one or more of the analytes on the line blot: ANNA1 (Hu), ANNA2 (Ri), PCA1 (Yo), Ma2/Ta, CV2 (CRMP5), Amphiphysin, AGNA1 (SOX1), GAD65, DNER, and Zic4. If the tissue mosaic pattern suggests ANNA3, then titer will be performed at an additional charge.
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
© 2026 HNL Lab Medicine. All rights reserved.