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Test Code
FLTIT
Test Name
FLT3 ITD and TKD Mutation Detection
CPT Codes
81245, 81246, G0452
Expected Turnaround Time
1 - 3 days
Clinical Utility

Presence of FLT3-ITD or FLT3-TKD mutations in Acute Myelogenous Leukemia (AML) provides prognostic information, to aid in the determination of therapeutic regimen.
Specimen and Container Info

Specimen

Container

Volume

Whole Blood

Lavender Top (EDTA)

1 mL

Bone Marrow

Sterile Container

1 mL
Processing and Submission Instructions
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

Bone Marrow, EDTA Blood: 7 days

Refrigerated

Bone Marrow, EDTA Blood: 7 days
Causes for Rejection
  • Any specimen with leakage on the outside of the container will be rejected. Ensure the lid is tightly closed.
  • Any specimen collected in an outdated collection vial will be rejected.
Methodology
Polymerase Chain Reaction (PCR)/Capillary Electrophoresis (CE)
Reference Intervals

No FLT3 Gene Variants Detected
Performing Location
Roble Road Core Laboratory
Alternate Names
  • FLT3 ITD
  • FLT3 TKD
  • FLT3 Mutation
  • FLT3 Gene Internal Tandem Duplication
  • FLT3 Gene Tyrosine Kinase Domain Mutation
Description

Test includes:

  • Internal Tandem Duplications (ITD) in exons 14 and 15 of FLT3 gene
  • Tyrosine Kinase Domain mutation D835Y in exon 20 of FLT3 gene
Testing Schedule
Routine, Monday - Friday no holidays
Genes
FLT3
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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