Test Directory

• Evaluation of neonatal hyperbilirubinemia, favism or chronic or episodic hemolysis or jaundice
• Evaluation for gamma-glutamylcysteine synthetase deficiency
• Evaluation for glutathione synthetase deficiency causing hemolytic anemia
• Evaluation for generalized glutathione synthetase deficiency with 5-oxoprolinuria

Specimen Type: Whole Blood

Collection Container: Pale Yellow Top (ACD, Solution B)

Desired Specimen Volume: 6 mL

1. Collect a pale-yellow top (ACD, Solution B) tube via venipuncture.

1. Transport 6 mL of whole blood in the original collection container.
2. Do not aliquot.

Transport to the laboratory refrigerated. 

• Gross hemolysis

 See patient report.

Samples with white blood cell counts greater than 20x10(9)/L have been shown to falsely increase the glutathione level by as much as 25%. Results in the normal or elevated range should be interpreted with caution if high white blood cell count is noted.

Recent transfusion may mask the patient's intrinsic enzyme activity and cause unreliable results.

• Glutathione Synthase
• Reduced Glutathione, Blood