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Test Code
PNHG
Test Name
High Sensitivity PNH Evaluation
Included Tests

Markers included are CD14, CD15, CD24, CD45, CD59, CD64, CD235a (Glycophorin A) and FLAER.
Expected Turnaround Time
2 - 4 days
Clinical Utility

Useful for diagnosing Paroxysmal Nocturnal Hemoglobinuria (PNH) and monitoring response to therapy. Small PNH clones may also be identified in patients with aplastic anemia and myelodysplastic syndrome (MDS) who may respond to immune modulation therapy. This test also identifies patients at increased risk of developing overt PNH.
Specimen and Container Info

Specimen Type: Peripheral Blood

Preferred Collection Container: Lavender Top (EDTA)

Alternate Collection Container: Green Top (Sodium Heparin)

Desired Specimen Volume: 3 mL

Minimum Acceptable Volume: 1 mL
Processing and Submission Instructions
  • Ship same day as drawn whenever possible.
  • Specimens must be received in the Flow Cytometry Department by 1400 on any Friday or the day before a holiday. This is to ensure samples are shipped same day and will meet the requirement of receipt at Neogenomics Laboratories within 48 hours of draw.
Transport Instructions

Transport to the laboratory refrigerated
Stability Requirements

Refrigerated

48 hours
Causes for Rejection
  • Incorrect specimen container
  • Incorrect specimen type (Bone marrow samples are unacceptable)
  • Frozen specimens
Methodology
Flow Cytometry
Limitations

In validation studies, this assay was shown to detect RBC and granulocyte PNH clones with frequency down to 0.01%
Performing Location
Roble Road Core Laboratory
Alternate Names
  • High Sensitivity PNH by Flow Cytometry
  • Paroxysmal Nocturnal Hemoglobinuria (PNH), High Sensitivity , RBC AND WBC
Reference Lab
Neogenomics Laboratories, Inc.
Testing Schedule
Routine, Monday - Friday no holidays
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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