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Test Code
HMGCR
Test Name
HMGCR Antibody
CPT Codes
82397
Expected Turnaround Time
1 - 5 days
Clinical Utility

Differential diagnosis of myositis in patients with or without statin exposure.
Specimen and Container Info

Specimen Type: Serum

  

Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 0.5 mL
Collection Instructions
  1. Collect a gold top, serum separator tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells ASAP or within 2 hours of collection.
  2. Transfer 0.5 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

48 hours

Refrigerated

14 days

Frozen

30 days
Causes for Rejection
  • Contaminated
  • Heat-inactivated
  • Clots/fibrin
  • Gross red blood cells
  • Severely lipemic
  • Severely hemolyzed
  • Severely icteric
Methodology
Chemiluminescent Immunoassay
Reference Intervals

See patient report.

Limitations

IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.
Alternate Names
  • HMG
  • HMG antibody
Reference Lab
ARUP Laboratories
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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