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Test Code
OVHE4
Test Name
Human Epididymis Protein 4 (HE4)
CPT Codes
86305
Expected Turnaround Time
5 days
Clinical Utility

The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay. Serial testing for patient HE4 assay values should be used in conjunction with methods used for monitoring ovarian cancer.
Specimen and Container Info

Specimen Type: Serum

Preferred Collection Container: Red Top, Plain

Alternate Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 0.5 mL
Collection Instructions
  1. Collect a red top, plain tube via venipuncture.
  2. Allow blood to clot for at least 30 minutes, but no longer than one hour.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 0.3 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory frozen. 
Stability Requirements

Room Temperature

48 hours

Refrigerated

72 hours

Frozen

28 days
Causes for Rejection
  • Gross hemolysis
  • Lipemia
  • Icteric specimens
  • Presence of fibrin, RBCs or other particulate matter
  • Obvious microbial contamination
Methodology
Chemiluminescent Microparticle Immunoassay (CMIA)
Reference Intervals

 See patient report.
Alternate Names
  • HE4, Ovarian Cancer Monitoring
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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