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Test Code
INSIT
Test Name
InSight® FISH
CPT Codes
88271 X 5, 88275
Expected Turnaround Time
2 - 3 days
Clinical Utility

This test is used for fluorescence in situ hybridization (FISH) and prenatal aneuploid evaluation FISH targeting numerical changes in 13, 18, 21, X, Y. If specimen volume is too small, then direct FISH may not be performed and results may be obtained if cultured chromosome studies are ordered.
Specimen and Container Info

Specimen Type: Amniotic Fluid

Collection Container: Sterile, Non-additive Container

Desired Specimen Volume: 5 mL
Collection Instructions
  1. Transport 5 mL of amniotic fluid in a sterile plastic conical tube.
Processing and Submission Instructions
  1. Pertinent medical findings should accompany request for FISH. It is required that InSight FISH testing be performed concurrently with prenatal chromosome analysis or microarray.
  2. Abnormal results should have banded chromosome confirmation.

**Requires Integrated Genetics Test Requisition**
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

 24 hours
Causes for Rejection
  • Frozen amniotic fluid
  • Wrong specimen type
  • Low specimen volume
  • Specimen in fixative
  • Glass containers and/or rubber stoppered tubes (rubber is toxic to amniocytes)
  • Hypocellular specimen.
Methodology
Fluorescence in situ hybridization (FISH)
Reference Intervals

 See patient report.
Limitations

Molecular mutations below the resolution of FISH will not be detected; will not detect aneuploidy that is not targeted by FISH probes in this panel.
Reference Lab
Integrated Genetics
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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