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Test Code
KEPRA
Test Name
Levetiracetam, Serum
CPT Codes
80177
Expected Turnaround Time
3 - 5 days
Clinical Utility
  • Identification and quantitation of levetiracetam.
  • Levetiracetam is an anticonvulsant used as adjunct therapy to treat adult partial seizures.
  • As multiple anticonvulsants are administered, it is important to optimize therapy, assure compliance, and avoid toxicity.
Specimen and Container Info

Preferred Specimen Type: Serum 

Preferred Collection Container: Red Top. Plain 

Desired Specimen Volume: 1 mL  
Collection Instructions

Collect at trough level, immediately prior to next dose.
Processing and Submission Instructions
  1. Allow specimen to sit upright 30 minutes.
  2. Centrifuge for 5 minutes at 3000 rpm within 2 hours of collection.
  3. Transfer serum to plastic vial and refrigerate.
Transport Instructions

Transport to the laboratory refrigerated.  
Stability Requirements

Room Temperature

48 hours

Refrigerated

14 days  

Frozen

30 days
Causes for Rejection

Specimens collected in separator tubes will be rejected.  
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Intervals

Analyte

Drug Dosage (mg BID)

Trough Level (µg/mL)

Peak Level (µg/mL)

Levetiracetam

500

3.1 - 10.0

10.0 - 25.0

Levetiracetam

1000

4.9 - 37.1

30.0 - 40.0

Levetiracetam

1500

7.0 - 34.0

36.1 - 70.0

 
Performing Location
Roble Road Core Laboratory
Alternate Names
  • Keppra
  • Elepsia
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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