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The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Alternate Collection Container: Red Top, Plain

Specimen Volume: 1 mL

1. Collect a gold top, serum separator tube via venipuncture.

1. Separate serum from cells
2. Transfer 1 mL of serum to a clear aliquot tube (screw cap).

Transport to the laboratory refrigerated. 

• Hemolysis
• Lipemia
• Gross bacterial contamination
• Heat treated
• Sample with preservative added

See patient report.

A negative LKM-1 result does not rule out the presence of autoimmune hepatitis type 2. LKM-1 may be detected in some patients as a result of HCV infection and may not be the result of AIH-2.

• LKM
• LKM-1 Antibodies