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Test Code
LRP4
Test Name
LRP4 Autoantibody
CPT Codes
86255
Expected Turnaround Time
17 - 18 days
Clinical Utility
Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK.
Specimen and Container Info

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 2 mL
Collection Instructions
  1. Collect a gold top, serum separator tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 2 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

72 hours

Refrigerated

25 days

Frozen

25 days
Methodology
Immunofluorescence Assay
Reference Intervals

See patient report.
Reference Lab
Quest Diagnostics Nichols Institute
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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