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Test Code
LYSAL
Test Name
Lysosomal Acid Lipase Activity
CPT Codes
82657
Included Tests
  • LAL Activity
  • Interpretation
Expected Turnaround Time
3 - 14 days
Clinical Utility

Diagnose Wolman disease and cholesteryl ester storage disease (CESD) caused by LAL deficiency.
Specimen and Container Info

Specimen Type: Whole Blood

Collection Container: Lavender Top (EDTA)

Alternate Collection Container: Tan Top (EDTA)

Desired Specimen Volume: 3 mL
Collection Instructions
  1. Collect a lavender top (EDTA) tube via venipuncture.
Processing and Submission Instructions
  1. Transport 3 mL of whole blood in the original collection container.
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Refrigerated

4 days
Causes for Rejection
  • Pink top EDTA tubes
  • Anticoagulant other than EDTA
  • Specimen clotted
  • Gross hemolysis
  • Frozen specimen
Methodology
Determination of enzyme activity against 4-methylumbelliferyl-palmitate
Reference Intervals

See patient report.
Limitations

This test is not appropriate for determination of carrier status, as some clinical conditions may result in indeterminate enzyme activity levels.
Alternate Names
  • Lysosomal Acid Lipase (LAL) Deficiency
  • Cholesteryl Ester Storage Disease (CESD)
  • Wolman Disease
Reference Lab
Labcorp Of America Holdings
Testing Schedule
Monday-Friday
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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