Test Directory

• OSBR Risk 1 IN
• AFP Value
• AFP MoM
• Interpretation

Screening test for open neural tube defects. Detects 80% of open spina bifida and 90% of anencephaly. Please note that this test does not provide screening for Down syndrome or trisomy 18.

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 3 mL

1. Open spina bifida screening is offered for gestational ages 15.0 to 23.9 weeks. The optimal gestational age for open spina bifida screening is 16.0 to 18.9 weeks. Collect specimen within these time frames.
2. Collect a gold top, serum separator tube via venipuncture.

1. Allow blood to clot, avoiding hemolysis.
2. Separate serum from cells.
3. Transport 3 mL of serum in the original collection tube. Do not aliquot. Pour-off is not advised.

• Specimens must be collected before amniocentesis to avoid contamination with fetal blood
• Open spina bifida screening is offered for gestational ages 15.0 to 23.9 weeks. The optimal gestational age for open spina bifida screening is 16.0 to 18.9 weeks

Transport to the laboratory refrigerated. 

• Gross hemolysis
• Gross lipemia
• Quantity not sufficient for analysis
• Improper specimen type

 See patient report.

MS-AFP is a screening test. This test does not screen for Down syndrome or trisomy 18. A positive result means that more diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect is present.

• AFP, Maternal Serum
• Alpha-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida
• Maternal Serum α-Fetoprotein
• msAFP