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Test Code
MOGAB
Test Name
MOG ANTIBODY CSF
CPT Codes
86362
Expected Turnaround Time
4 - 8 days
Clinical Utility
Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.
Specimen and Container Info

Specimen Type: Cerebrospinal Fluid

 

Collection Container: Sterile, Non-additive Container (CSF) 

Desired Specimen Volume: 2 mL
Collection Instructions
  1. Collect CSF via lumbar puncture.
Processing and Submission Instructions
  1. Transfer 2 mL of CSF to a sterile aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

7 days

Refrigerated

14 days

Frozen

21 days
Causes for Rejection
  • Visible particulate matter
Methodology
Cell-based Immunofluorescence Assay
Reference Intervals

See patient report.
Alternate Names
  • Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, CSF
  • Transverse Myelitis Antibody,
  • MOG-IgG
  • Myelin oligodendrocyte glycoprotein
  • NMO Spectrum Disorder,
  • LETM antibody
  • Optic Neuritis Antibody
  • ADEM antibody
  • NMOSD
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Routine, 1 time per week
Reflex Tests
MGTCS
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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