Test Directory

Test Code
MUSK
Test Name
Muscle-Specific Kinase (MuSK) Autoantibody
CPT Codes
86366
Expected Turnaround Time
4 - 8 days
Clinical Utility

Detection of antibodies to muscle-specific receptor tyrosine kinase (MuSK) (titer test). MuSK autoantibodies are detected using an RIA; a titer of 1:10 or greater is considered positive for antibody presence and provides a definitive diagnosis of MG.

Specimen and Container Info

Specimen Type: Serum

Preferred Collection Container: Red Top, Plain

Alternate Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 2 mL

Collection Instructions
  1. Collect a red top, plain tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells within 48 hours of collection.
  2. Transfer 2 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 

Stability Requirements

Room Temperature

72 hours

Refrigerated

42 days

Frozen

1 year

Causes for Rejection
  • Hemolysis
  • Lipemia
Methodology
Radioimmunoassay
Reference Intervals

See patient report.

Alternate Names
  • MuSK Antibody Test
  • muscle-specific receptor tyrosine kinase
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Routine, 6 times per week