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Test Code
MDPRG
Test Name
MYD88 Mutation
Included Tests

Bi-directional sequencing of exon 5 of the MYD88 gene which includes detection of the common L265P mutation.
Expected Turnaround Time
7 - 10 business days
Clinical Utility

MYD88 mutation is the most common genetic abnormality in the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), detected in 40% of cases. Mutations are rare in the germinal center B-cell-like (GCB) subtype, so mutation analysis can be useful to differentiate between the ABC and GCB subtypes. The L265P mutation is present in >90% of Waldenstrom's macroglobulinemia (WM) and has been associated with increased risk of progression to WM in IgM MGUS patients. MYD-88 is also implicated in the susceptibility to BTK inhibitors in the treatment of B-cell neoplasms.
Specimen and Container Info

Specimen

Container

Preferred Volume

Minimum Volume

Peripheral Blood

Lavender Top (EDTA)

5 mL

3 mL

Bone Marrow

Lavender Top (EDTA)

2 mL

1 mL

Fresh Tissue

RPMI

One piece, 1 cm³

One piece, 0.5 cm³

FFPE Tissue

Paraffin block

Paraffin Block

1 H&E slide plus 5-10 unstained slides cut at 5 or more microns from paraffin block
Collection Instructions

Please exclude biopsy needles, blades, and other foreign objects from collection containers.
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Refrigerated

72 hours
Causes for Rejection
All specimens will be rejected if they are frozen.
Methodology
Molecular
Performing Location
Roble Road Core Laboratory
Alternate Names
Myeloid Differentiation Primary Response 88
Reference Lab
Neogenomics Laboratories, Inc.
Testing Schedule
Routine, Monday - Friday no holidays
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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