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Test Code
MOGFS
Test Name
Myelin Oligodendrocyte Glycoprotein
CPT Codes
86363
Expected Turnaround Time
5 - 8 days
Clinical Utility
Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica (NMO) spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis

Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
Diagnosis of NMO

Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease

Diagnosis of ADEM

Prediction of a relapsing disease course
Specimen and Container Info

Specimen Type: Serum

Preferred Collection Container: Red Top, Plain

Alternate Collection Container: Gold Top, Serum Separator

Desired Specimen Volume: 2 mL
Collection Instructions
  1. Collect a red top, plain tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 2 mL of serum to a clear aliquot tube (screw cap).
Patient Preparation

For optimal antibody detection, specimen collection should occur prior to initiation of immunosuppressant medication.
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

72 hours

Refrigerated

28 days

Frozen

28 days
Causes for Rejection
  • Gross hemolysis
  • Gross lipemia
  • Gross icterus
Methodology
Flow Cytometry
Reference Intervals

See patient report.
Limitations

Myelin oligodendrocyte glycoprotein (MOG)-IgG, specifically MOG-IgG1, may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Alternate Names
  • MOG-IgG
  • MOG
  • Optic Neuritis Antibody
  • Transverse Myelitis Antibody
  • Vision Loss Antibody
  • ADEM antibody
  • NMO antibody
Reference Lab
Mayo Clinic Laboratories
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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