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Test Code
OCAMY
Test Name
Myeloid Cancer Panel by NGS
CPT Codes
81455, G0452
Expected Turnaround Time
13 - 14 days
Clinical Utility
The NGS Myeloid Cancer Panel is intended for use to help guide health care professionals in cancer treatment management for patients with myeloid disorders associated with acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN) and chronic myeloid leukemia (CML) in accordance with professional guidelines. The identification of genomic variants will identify patients who may benefit from treatment with specific FDA-approved targeted therapies, or in the use of other targeted oncology therapies. The results may also identify patient opportunities for participation in clinical trials.
Specimen and Container Info

Specimen

Containers

Volume

Whole Blood

Lavender Top (EDTA)

1 mL

Bone Marrow

Sterile Container

1 mL
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Room Temperature

Bone Marrow, EDTA Blood: 7 days

Refrigerated

Bone Marrow, EDTA Blood: 7 days

Frozen

Bone Marrow, EDTA Blood: 30 days
Causes for Rejection
  • Any specimen with leakage on the outside of the container will be rejected. Ensure the lid is tightly closed.
  • Any specimen collected in an outdated collection vial will be rejected.
Methodology
Next Gen Sequencing (NGS)
Reference Intervals
No Variants Detected
Performing Location
Roble Road Core Laboratory
Alternate Names
  • Myeloid Cancer Panel by Next Generation Sequencing
  • NGS Myeloid Panel with Interpretation
Description
  • Detection of single nucleotide variants (SNV) and Insertions-Deletions (Indels) in 40 DNA genes; ABL1, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, IKZF1, JAK2, KIT, KRAS, MPL, MYD88, NF1, NPM1, NRAS, PHF6, PRPF8, PTPN11, RB1, RUNX1, SETBP1, SF3B1, SH2B3, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2
  • Detection of RNA fusions from 29 driver genes: ABL1, ALK, BCL2, BRAF, CCND1, CREBBP, EGFR, ETV6, FGFR1, FGFR2, FUS, HMGA2, JAK2, KMT2A (MLL), MECOM, MET, MLLT10, MLLT3, MYBL1, MYH11, NTRK3, NUP214, PDGFRA, PDGFRB, RARA, RBM15, RUNX1, TCF3, TFE3
Testing Schedule
Routine, Monday - Friday no holidays
Genes
ABL1, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, IKZF1, JAK2, KIT, KRAS, MPL, MYD88, NF1, NPM1, NRAS, PHF6, PRPF8, PTPN11, RB1, RUNX1, SETBP1, SF3B1, SH2B3, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2, ALK, BCL2, CCND1, CREBBP, EGFR, FGFR1, FGFR2, FUS, HMGA2, , KMT2A (MLL), MECOM, MET, MLLT10, MLLT3, MYBL1, MYH11, NTRK3, NUP214, PDGFRA, PDGFRB, RARA, RBM15, TCF3, TFE3.
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