Test Directory

NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

Specimen Type: Serum

Collection Container: Gold Top, Serum Separator

Alternate Collection Container: Red Top, Plain

Desired Specimen Volume: 2 mL

1. Collect a gold top, serum separator tube via venipuncture

1. Separate serum from cells.
2. Transfer 2 mL of serum to a clear aliquot tube (screw cap).

Transport to the laboratory refrigerated. 

• CSF or plasma
• Contaminated, hemolyzed, or severely lipemic specimens

See patient report.

Results should not be used as a diagnostic procedure without confirmation by another medically established diagnostic product or procedure.

• Anti-N-methyl-D-Aspartate Receptor (NMDAR), Serum