Test Directory

NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

Specimen Type: Cerebrospinal Fluid

Collection Container: Sterile, Non-Additive Container (CSF) 

Desired Specimen Volume: 2 mL

1. Collect CSF via lumbar puncture.

1.  Transfer 2 mL of CSF to a sterile clear aliquot tube (screw cap).

Transport to the laboratory refrigerated. 

• Gross hemolysis
• Grossly lipemic
• Gross icterus

 See patient report.

• Anti-N-methyl-D-Aspartate Receptor (NMDAR), Spinal Fluid
• Anti-NMDAR, Spinal Fluid
• Autoimmune Dementia Panel Spinal Fluid
• Paraneoplastic