Test Directory

Test Code
BTO
Test Name
Opiates, Total, Quantitative, Whole Blood
CPT Codes
AMA 80361, 80365, CMS G0480
Expected Turnaround Time
5 - 7 days
Clinical Utility

To assess the recent use of opiates and measure the Total Opiates (conjugated and unconjugated) concentrations in blood.

Testing includes identification and quantitation of:

  • Codeine
  • Morphine
  • Hydrocodone
  • Hydromorphone
  • Oxycodone
  • Oxymorphone
Specimen and Container Info

Specimen

Container

Volume

Whole Blood

Grey Top* (Sodium Fluoride, Potassium Oxalate)

3 mL

Whole Blood

Dark Green Top (Lithium Heparin)

3 mL

Whole Blood

Lavender Top (EDTA)

3 mL

Serum

Red Top, Plain

1 mL

*Preferred Specimen

Processing and Submission Instructions

For forensic or legal purposes, submit specimen in a plastic evidence bag with a Chain-of-Custody Form.

Transport Instructions

Transport to the laboratory refrigerated.

Causes for Rejection

Specimens collected in separator tubes will be rejected.

Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Intervals

Analyte

Therapeutic range (ng/mL)

Morphine

Dependent on drug dosage

Codeine

30-340

Hydrocodone

30-250

Hydromorphone

8-50

Oxycodone

10-100

Oxymorphone

Not established

6MAM

None detected

 

Limitations

Analyte

Reporting Limit (ng/mL)

Codeine

5

Morphine

5

Hydrocodone

5

Hydromorphone

5

Oxycodone

5

Oxymorphone

5

6MAM

2

Performing Location
Roble Road Core Laboratory
Alternate Names

Opiates

Codeine Alternate Names:

  • Tylenol with Codeine
  • Pyregesic-C
  • Tylenol No 3
  • Tylenol #3
  • Paracetamol and codeine
  • Codeine

Morphine Alternate Names:

  • Arymo Er
  • Kadian
  • MS Contin
  • Morphabond
  • Oramorph SR
  • Roxanol
  • AVINza
  • Morphine

6MAM Alternate Names:

  • Heroin metabolite
  • Monoacetylmorphine
  • Acetylmorphine
  • 6MAM

Hydroocodone Alternate Names:

  • Vicodin
  • Lorcet
  • Zamicet
  • Xodol
  • Vicoprofen
  • Hydrocodone

Hydromorphone Alternate Names:

  • Dilaudid
  • Exalgo
  • Palladone
  • Hydromorphone

Oxycodone Alternate Names:

  • Oxycontin
  • Percocet
  • Oxy
  • Roxicet
  • Tylox
  • Endocet
  • Opana (Oxymorphone)
  • Numorphan (Oxymorphone)
  • Opana ER (Oxymorphone)
  • Oxycodone
  • Oxymorphone
Testing Schedule
Routine, 2 times per week