Test Directory
| Test Code | |||||||||||||
| PMLNG | |||||||||||||
| Test Name | |||||||||||||
| PML-RARA Translocation, t(15:17) Quantitative Analysis | |||||||||||||
| CPT Codes | |||||||||||||
| 81315 | |||||||||||||
| Included Tests | |||||||||||||
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Real-time RT-PCR for quantitative detection of the t(15;17) PML-RARA fusion transcript. Both long and short isoforms of the fusion transcript are detected. Positive results identify the isoform and quantify it as a ratio with the amount of transcript from a normal control gene. |
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| Expected Turnaround Time | |||||||||||||
| 7 - 10 business days | |||||||||||||
| Clinical Utility | |||||||||||||
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The (15;17) translocation occurs in nearly all cases of acute promyelocytic leukemia (APL) also known as Acute Myeloid Leukemia (AML) subtype M3. The translocation is associated with a high rate of complete remission due to sensitivity of leukemic cells to all trans-retinoic acid (ATRA). This assay is recommended for diagnostic confirmation and initiation of ATRA therapy, for monitoring minimal residual disease (MRD), and for detection of relapse. |
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| Specimen and Container Info | |||||||||||||
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| Processing and Submission Instructions | |||||||||||||
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Ship same day as drawn whenever possible |
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| Transport Instructions | |||||||||||||
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Transport to laboratory refrigerated. |
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| Stability Requirements | |||||||||||||
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| Causes for Rejection | |||||||||||||
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| Methodology | |||||||||||||
| Molecular | |||||||||||||
| Limitations | |||||||||||||
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Analytic sensitivity is 1 tumor cell in 10,000 normal cells. |
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| Performing Location | |||||||||||||
| Roble Road Core Laboratory | |||||||||||||
| Alternate Names | |||||||||||||
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| Reference Lab | |||||||||||||
| Neogenomics Laboratories, Inc. | |||||||||||||
| Testing Schedule | |||||||||||||
| Routine, Monday - Friday no holidays | |||||||||||||
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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