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Overgrowth syndromes are characterized by pre- and postnatal overgrowth, accelerated osseous maturation, a characteristic craniofacial appearance, and developmental delay. All of these syndromes show considerable phenotypic overlap; however, these disorders also have some distinct clinical features.  Congenital heart anomalies, scoliosis, renal abnormalities and seizures are common in Sotos syndrome, while Weaver syndrome is associated with campodactyly, umbilical hernia, a hoarse cry in infancy, and soft, doughy skin. Cohen-Gibson syndrome is clinically related to Weaver syndrome. Simpson-Golabi-Behmel syndrome, type 1 can be distinguished from other overgrowth disorders by its unique set of features, including coarse facies, macrostomia, macroglossia, cleft palate, postaxial polydactyly, rib abnormalities, and congenital heart defects. Simpson-Golabi-Behmel syndrome, type 2 clinically overlaps with Simpson-Golabi-Behmel syndrome, type 1. Simpson-Golabi-Behmel syndrome, type 2 is more severe and often lethal in infancy. Patients with multiple congenital anomalies-hypotonia-seizures syndrome 2  have multiple congenital anomalies, neonatal hypotonia and myoclonic seizures. Kosaki overgrowth syndrome is associated with hyperelastic skin, premature aging and neurodegeneration. In addition to skeletal overgrowth Marfan syndrome is characterized by ocular and cardiovascular features. Additional clinical features in Luscan-Lumish syndrome include macrocephaly, behavioral problems and seizures.