Test Directory

Test Code
SJO
Test Name
Sjogren's Autoantibody Profile
CPT Codes
86235 X 2
Included Tests
  • SSA (Ro) Autoantibody
  • SSB (La) Autoantibody
Expected Turnaround Time
4 - 7 days
Clinical Utility

This panel is used to aid the diagnosis of Sjogren's Syndrome. One or both of the autoantibodies are detected in 80-90% of Sjogren's Syndrome (SS) and 30 - 35% of patients with Systemic Lupus erythematosus (SLE). SSA and SSB antibodies detected in 96% of patients with primary (SS) and in all patients with SS secondary to Rheumatoid Arthritis (RA). SSA and SSB are rarely detected in SS secondary to RA, progressive systemic sclerosis, and primary biliary cirrhosis.

Specimen and Container Info

Preferred Specimen Type: Serum

Desired Specimen Volume: 2 mL

Preferred Collection Container: Gold Top, Serum Separator

Processing and Submission Instructions

Separator tubes: Contains clot activator and gel for separating serum from cells, but not anticoagulant. Separate serum from cells as soon as the clot has formed (30 minutes). If specimen is centrifuged before clotting is complete, a fibrin clot will form on top of the cell. This may cause the gel barrier to not be intact and could cause improper separation of serum and cells, possibly affecting test results.

Transport Instructions

Transport refrigerated.

Stability Requirements

Refrigerated

14 days

Frozen

<20°C for long-term storage.  

Freeze/Thaw Cycles

Avoid multiple freeze/thaw cycles. 

Methodology
Semi-Quantitative Multiplex Bead Assay
Reference Intervals

<1.0 AI, Negative 

Performing Location
Roble Road Core Laboratory
Testing Schedule
Routine, Monday - Friday no holidays