Test Directory

Test Code
HYSUQ
Test Name
Sulfonylureas Qualitative, Hypoglycemia Panel
CPT Codes
AMA 80377, CMS G0480
Included Tests
  • Chlorpropamide
  • Glimepiride
  • Glipizide
  • Glyburide
  • Nateglinide
  • Repaglinide
  • Tolazamide
  • Tolbutamide
  • Rosiglitazone
  • Pioglitazone
Expected Turnaround Time
4 - 7 days
Clinical Utility

Useful for the evaluation of suspected insulinoma characterized by hypoglycemia and increased serum insulin concentration. Useful for detecting drugs that stimulate insulin secretion.

Specimen and Container Info

Specimen Type: Serum

Collection Container: Red Top, Plain

Desired Specimen Volume: 1.5 mL

Collection Instructions
  1. Collect a red top, plain tube via venipuncture
Processing and Submission Instructions
  1. Separate serum from cells.
  2. Transfer 1.5 mL of serum to a clear aliquot tube (screw cap).
Patient Preparation

Specimen must be collected during an episode of hypoglycemia.

Transport Instructions

Transport to the laboratory refrigerated. 

Stability Requirements

Room Temperature

7 days

Refrigerated

28 days

Frozen

28 days

Methodology
Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Reference Intervals

See patient report.

Limitations

This test is not intended for therapeutic drug monitoring but could be used to monitor compliance.

Proper interpretation requires that the specimen be collected during or close to the time of a hypoglycemic episode. Drugs will not be detected (and are not likely to be present) if blood is drawn when blood glucose is normal in nondiabetic patients.

Alternate Names
  • Sulfonylurea Hypoglycemic Serum
  • Hypoglycemic Agents
  • Hypoglycemic Agent Screen
  • HYPOG
Reference Lab
Mayo Clinic Laboratories
Testing Schedule
Routine, 3 times per week