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Test Code

TCPCR

Test Name

T Cell Gene Rearrangement

Included Tests

Clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions
Qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis

Expected Turnaround Time

7 - 10 business days

Clinical Utility

T-cell receptor (TCR) gene rearrangement analysis is commonly used for determining clonality in the diagnostic evaluation of T-cell lymphomas and leukemias.
TCR gamma and beta gene rearrangement analysis together will detect most clonal TCR rearrangements in patients with T-cell Lymphomas/leukemias.
Results should be interpreted in clinical context for diagnosis of T-cell lymphoproliferative disorders.

Specimen and Container Info

Specimen	Container	Preferred Volume	Acceptable Volume
Peripheral Blood	Lavender Top (EDTA)	5 mL	3 mL
Bone Marrow	Lavender Top (EDTA)	2 mL	1 mL
Fresh Tissue	RPMI	Two pieces minimum, 0.2 cm³	One piece minimum, 0.2 cm³
FFPE Tissue	Paraffin Block	Paraffin Block	1 H&E slide plus 5-10 unstained slides cut at 5 or more microns from paraffin block

Collection Instructions

Please exclude biopsy needles, blades, and other foreign objects from collection containers.

Transport Instructions

Transport to the laboratory refrigerated.

Stability Requirements

Refrigerated

72 Hours

Causes for Rejection

Methodology

Molecular

Performing Location

Roble Road Core Laboratory

Alternate Names

Reference Lab

Neogenomics Laboratories, Inc.

Testing Schedule

Routine, Monday - Friday no holidays