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Test Code
TP53S
Test Name
TP53 Somatic Mutation, Prognostic
CPT Codes
81352
Expected Turnaround Time
3 - 4 days
Clinical Utility

Somatic mutation of the p53 tumor suppressor gene is the most common genetic alteration seen in human cancers, with >50% of adult human tumors bearing inactivating mutations or insertions, deletions in the P53 gene. Wild type p53 prevents genetic instability and participates in the apoptotic response to radiotherapy and chemotherapy. Mutations in P53 gene usually correlate with poor outcome and early recurrence in cancer. This test provides important prognostic and prodictive information for patients with B-CLL, breast cancer, cervical cancer, melanoma or other cancers.
Specimen and Container Info

Specimen Type: Whole Blood

  

Collection Container: Lavender Top (EDTA)

Desired Specimen Volume: 6 mL
Collection Instructions
  1. Collect 2 lavender top (EDTA) tubes via venipuncture.
Processing and Submission Instructions
  1. Transport 6 mL of whole blood in the original collection containers.
Transport Instructions

Transport to the laboratory refrigerated.
Stability Requirements

Room Temperature

72 hours

Refrigerated

7 days
Methodology
Next Gen Sequencing (NGS)
Reference Intervals

See patient report.
Reference Lab
Quest Diagnostics Nichols Institute
Testing Schedule
Routine, 2 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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