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Test Code
VRCZS
Test Name
Voriconazole, Serum
CPT Codes
80285
Expected Turnaround Time
1 - 2 day
Clinical Utility
Monitoring trough levels of voriconazole is suggested for:

-Individuals with reduced liver function
-Individuals with cytochrome P450 (CYP) 2C19 alterations associated with poor metabolic function
-Patients taking other medications that affect CYP2C19 activity
-Patients experiencing potential toxicity

Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels or to ensure adequate oral absorption
Specimen and Container Info

Specimen Type: Serum

Collection Container: Red Top, Plain

Desired Specimen Volume: 2 mL
Collection Instructions
  1. Collect a red top, plain tube via venipuncture.
Processing and Submission Instructions
  1. Separate serum from cells within 2 hours of collection.
  2. Transfer 2 mL of serum to a clear aliquot tube (screw cap).
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

28 days

Refrigerated

28 days

Frozen

28 days
Methodology
Liquid Chromatography - Tandem Mass Spectrometry (Lc/Ms/Ms)
Reference Intervals

See patient report.
Limitations

Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit cytochrome P450 2C19 or by genetic alterations that affect enzyme activity.
Alternate Names
  • Vfend (Voriconazole)
Reference Lab
Mayo Clinic Laboratories
Testing Schedule
Routine, daily
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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