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Test Code
ZONE
Test Name
Zonisamide, Serum
CPT Codes
80203
Expected Turnaround Time
1 - 5 days
Clinical Utility

Identification and quantitation of zonisamide.

Zonisamide is commonly used as an adjunct together with other conventional anticonvulsants.

As multiple drugs are administered, it is important to monitor the level to optimize therapeutic effects, to assure compliance and avoid toxicity.
Specimen and Container Info

Preferred Specimen Type:  Serum

Preferred Collection Container: Red Top, Plain

Desired Specimen Volume: 1 mL
Processing and Submission Instructions
  1. Allow specimen to sit upright 30 minutes.
  2. Centrifuge for 5 minutes at 3000 rpm within 2 hours of collection.
  3. Transfer serum to plastic vial and refrigerate.
Transport Instructions

Transport to the laboratory refrigerated. 
Stability Requirements

Room Temperature

 48 hours

Refrigerated

 14 days

Frozen

 30 days
Causes for Rejection

Specimens collected in separator tubes will be rejected.  
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Intervals

Analyte

Therapeutic Range (µg/mL)*

Zonisamide

10.0 - 40.0

 *Proposed therapeutic range for seizure control.
Critical Values

 Analyte

Critical Value (µg/mL)

Zonisamide

>80
Performing Location
Roble Road Core Laboratory
Alternate Names
  • Zonegran
  • Excegran
Testing Schedule
Routine, 3 times per week
The American Medical Association (AMA) Current Procedural Terminology (CPT) codes published by HNL Lab Medicine are guidelines and are intended for informational purposes only. CPT coding is the exclusive responsibility of the billing entity. View the Terms.
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